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If you have two RAM slots, it doesn’t matter which slot you use for your RAM, but if you have four or more, it does matter.

Most of NVMe SSDs use the M.2 form factor, but not all M.2 slots support NVMe - some M.2 slots only support SATA-based SSDs, so it's better to check your motherboard’s manual to see which type of M.2 drives it supports.